Clinical Application of Recombinant Thyroid Peroxidase
نویسندگان
چکیده
منابع مشابه
Relationship between Anti-Thyroid Peroxidase Antibody and Thyroid Function Test
Background: Anti-thyroid peroxidase antibody (anti-TPO antibody) is a member of thyroid autoantibodies which are important in inducing and also diagnosing autoimmune thyroid diseases. Thyroid autoimmunity can cause several forms of thyroiditis and abnormal thyroid functions, ranging from hypothyroidism to hyperthyroidism. Objective: To evaluate the relationship between serum levels of anti-TPO ...
متن کاملAnti-Thyroid Peroxidase and Risk of Recurrent Spontaneous Abortion
Background Approximately 2-4% of all women have recurrent spontaneous abortion (RSA); however, the cause is determined in only 50% of cases. Recent studies have shown an association between thyroid autoantibodies as a sign of thyroid autoimmunity and abortion. The aim of the present study was to determine whether circulating anti-thyroid peroxidase (anti-TPO) was associated with RSA. MaterialsA...
متن کاملIdentification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease
Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses ...
متن کاملThyroid peroxidase autoantigen : localization of autoantigenic epitopes on recombinant protein and prediction of secondary structure
The cloning and expression of TPO as a recombinant protein has allowed progress on the characterisation of the autoantigenic epitopes recognised by autoantibodieJ. fhe main immunogenic region of the molecule recognised by autoaniibodies has been localized to the carboxyl terminal. Multiple sequence alignment and secondary structure prediction methods used in conjunction with circular dichroic s...
متن کاملRecognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase.
To characterize the nature of thyroid peroxidase (TPO) autoantibodies present in the sera of patients with autoimmune thyroid disease, we cloned three IgG1/kappa Fab fragments which bind 125I-TPO. This was accomplished by the molecular cloning and expression in bacteria of IgG gene fragments from B cells infiltrating the thyroid of a patient with Graves' disease. The three Fab fragments (SP2, S...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1993
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.69.11_1123